General description
A cell-permeable anti-inflammatory sesquiterpene lactone that acts as a specific NF-κB-DNA binding inhibitor by irreversibly alkylating free sulfhydryls of the cysteine residues on the p65 subunit. Exhibits no effect against the DNA-binding activity of the homodimer of p50 subunit, nor does it affect cellular NF-κB activation/nuclear translocation or IκB dissociation/degradation. An excellent research tool for studying NF-κB-mediated biological processes both in cultures in vitro and in animals in vivo.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Boulanger, D., et al. 2007. Vet. Microbiol.119, 330. Auld, C.A., et al. 2006. Biochem. Biophys. Res. Commun.346, 314.Huang, P.R., et al. 2005. Cancer Lett.227, 169.Lyss, G., et al. 1998. J. Biol. Chem.273, 33508.Lyss, G., et al. 1997. Biol. Chem.378, 951.
Packaging
500 µg in Glass bottle
Packaged under inert gas
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Toxic (F)
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